Water-soluble Dioxidovanadium(V) complexes of Aroylhydrazones: DNA/BSA interactions, hydrophobicity, and cell-selective anticancer potential

Sahu, G. and Banerjee, A. and Samanta, R. and Mohanthy, M. and Lima, S. and Tiekink, Edward R. T. * and Dinda, R. (2021) Water-soluble Dioxidovanadium(V) complexes of Aroylhydrazones: DNA/BSA interactions, hydrophobicity, and cell-selective anticancer potential. Inorganic Chemistry, 60 (20). pp. 15291-15309. ISSN 1520-510X

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Official URL: https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c0...

Abstract

Five new anionic aqueous dioxidovanadium(V) complexes, [{VO2L1,2}A(H2O)n]α (1–5), with the aroylhydrazone ligands pyridine-4-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L1) and furan-2-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L2) incorporating different alkali metals (A = Na+, K+, Cs+) as countercation were synthesized and characterized by various physicochemical techniques. The solution-phase stabilities of 1–5 were determined by time-dependent NMR and UV–vis, and also the octanol/water partition coefficients were obtained by spectroscopic techniques. X-ray crystallography of 2–4 confirmed the presence of vanadium(V) centers coordinated by two cis-oxido-O atoms and the O, N, and O atoms of a dianionic tridentate ligand. To evaluate the biological behavior, all complexes were screened for their DNA/protein binding propensity through spectroscopic experiments. Finally, a cytotoxicity study of 1–5 was performed against colon (HT-29), breast (MCF-7), and cervical (HeLa) cancer cell lines and a noncancerous NIH-3T3 cell line. The cytotoxicity was cell-selective, being more active against HT-29 than against other cells. In addition, the role of hydrophobicity in the cytotoxicity was explained in that an optimal hydrophobicity is essential for high cytotoxicity. Moreover, the results of wound-healing assays indicated antimigration in case of HT-29 cells. Remarkably, 1 with an IC50 value of 5.42 ± 0.15 μM showed greater activity in comparison to cisplatin against the HT-29 cell line.

Item Type: Article
Uncontrolled Keywords: Anions; Ligands; Genetics; Cells; Toxicity
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Biofunctional Molecules Discovery Centre [formerly Research Centre for Crystalline Materials until 2023]
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 01 Nov 2021 05:52
Last Modified: 31 Dec 2021 03:34
URI: http://eprints.sunway.edu.my/id/eprint/1872

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