Development of oncolytic viruses for cancer therapy

Noraini Abd Aziz, * and Poh, Chit Laa * (2021) Development of oncolytic viruses for cancer therapy. Translational Research: The Journal of Laboratory and Clinical Medicine. ISSN 1931-5244 (In Press)

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Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies.

Item Type: Article
Uncontrolled Keywords: Oncolytic virus; Cancer; Combination therapy; Clinical trials
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 14 Jul 2021 05:34
Last Modified: 14 Jul 2021 05:34

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