Wong, M. M. T. and Chan, H. Y. and Norazlin, A. A. and Thamil Selvee, R. and Bong, J. J. and Ch’ng, E. S. and Armon, Subasri and Peh, Suat Cheng * and Teow, Sin Yeang * (2021) Interplay of autophagy and cancer stem cells in hepatocellular carcinoma. Molecular Biology Reports. pp. 1-23. ISSN 0301-4851
Full text not available from this repository.Abstract
Liver cancer is the sixth most common cancer and the fourth leading cause of cancer deaths in the world. The most common type of liver cancers is hepatocellular carcinoma (HCC). Autophagy is the cellular digestion of harmful components by sequestering the waste products into autophagosomes followed by lysosomal degradation for the maintenance of cellular homeostasis. The impairment of autophagy is highly associated with the development and progression of HCC although autophagy may be involved in tumour-suppressing cellular events. In regards to its protecting role, autophagy also shelters the cells from anoikis- a programmed cell death in anchorage-dependent cells detached from the surrounding extracellular matrix which facilitates metastasis in HCC. Liver cancer stem cells (LCSCs) have the ability for self-renewal and differentiation and are associated with the development and progression of HCC by regulating stemness, resistance and angiogenesis. Interestingly, autophagy is also known to regulate normal stem cells by promoting cellular survival and differentiation and maintaining cellular homeostasis. In this review, we discuss the basal autophagic mechanisms and double-faceted roles of autophagy as both tumour suppressor and tumour promoter in HCC, as well as its association with and contribution to self-renewal and differentiation of LCSCs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Liver cancer; Autophagy; Cancer stem cells; Hepatocellular carcinoma; Tumour progression; Suppression; Sirtuin 1 |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Dr Janaki Sinnasamy |
| Related URLs: | |
| Date Deposited: | 12 May 2021 09:37 |
| Last Modified: | 12 May 2021 09:37 |
| URI: | http://eprints.sunway.edu.my/id/eprint/1752 |
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