Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography

Khalid, A. and Ahmad, P. and Alharthi, A. I. and Muhammad, S. and Khandaker, Mayeen Uddin * and Faruque, M. R. I. and Din, I. U. and Alotaibi, M. A. (2021) Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography. Crystals, 11 (2). p. 171. ISSN 2073-4352

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Official URL: http://doi.org/10.3390/cryst11020171

Abstract

Highly crystalline titanium dioxide nanoparticles (TiO2 -NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2 -NPs are tested for improvement in two modes of kilovoltage radiation therapy and singlephoton emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2 -NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2 -NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2 -NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

Item Type: Article
Uncontrolled Keywords: nanoparticles; titanium dioxide; highly crystalline; computed tomography
Subjects: R Medicine > R Medicine (General) > R895-920 Medical Physics/Medical Radiology
Divisions: Others > Non Sunway Academics
Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Research Centre for Applied Physics and Radiation Technologies
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 19 Apr 2021 03:59
Last Modified: 19 Apr 2021 03:59
URI: http://eprints.sunway.edu.my/id/eprint/1668

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