Khalid, A. and Ahmad, P. and Alharthi, A. I. and Muhammad, S. and Khandaker, Mayeen Uddin * and Faruque, M. R. I. and Din, I. U. and Alotaibi, M. A. (2021) Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography. Crystals, 11 (2). p. 171. ISSN 2073-4352
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Abstract
Highly crystalline titanium dioxide nanoparticles (TiO2 -NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2 -NPs are tested for improvement in two modes of kilovoltage radiation therapy and singlephoton emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2 -NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2 -NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2 -NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.
| Item Type: | Article |
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| Uncontrolled Keywords: | nanoparticles; titanium dioxide; highly crystalline; computed tomography |
| Subjects: | R Medicine > R Medicine (General) > R895-920 Medical Physics/Medical Radiology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Research Centre for Applied Physics and Radiation Technologies [merged with Centre for Carbon Dioxide Capture and Utilization wef December 2023] |
| Depositing User: | Dr Janaki Sinnasamy |
| Related URLs: | |
| Date Deposited: | 19 Apr 2021 03:59 |
| Last Modified: | 19 Apr 2021 03:59 |
| URI: | http://eprints.sunway.edu.my/id/eprint/1668 |
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