Cyclotron production of no carrier added 186gRe radionuclide for theranostic applications

Khandaker, Mayeen Uddin * and Nagatsu, K. and Minegishi, K. and Zhang, M. R. and Jalilian, A. R. and Bradley, D..A. (2020) Cyclotron production of no carrier added 186gRe radionuclide for theranostic applications. Applied Radiation and Isotopes, 166. p. 109428. ISSN 0969-8043

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186gRe (T1/2 = 3.7183 d, E(β−)mean = 346.7 keV, I(β−)mean = 92.59%), a mixed beta and γ-emitter shows great potential for use in theranostic applications. The dominant 185Re(n,γ) route, via use of a nuclear reactor, provides 186gRe in carrier added form with low specific activity, while cyclotrons offer no carrier-added (NCA) high specific activity production of 186gRe. However, to be able to select the best possible nuclear reaction and to optimize the production route via the use of a cyclotron, information on the excitation function for the reaction of interest as well as for the competing reactions is necessary. Accordingly, we have conducted a detailed study of the excitation functions for natW(d, x) reactions in seeking optimized parameters for the NCA production of 186gRe. Noting a discrepancy among the experimental data, we made an evaluation of the available literature, finally selecting optimum parameters for the production of 186gRe via the 186W(d,2n)186Re reaction. These beam parameters were then used for batch production of 186gRe by irradiating an enriched 186W metallic powder target, followed by a subsequent automated chemical separation process. The preliminary results show 98.1% radionuclidic purity of 186gRe at 8 h subsequent to the End of Bombardment (EOB), offering the potential for use in clinical applications.

Item Type: Article
Uncontrolled Keywords: Deuteron cyclotron; Enriched 186W powder; Theranostic 186gRe; Excitation function; Chemical separation; NCA production; High radionuclidic purity product
Subjects: R Medicine > R Medicine (General) > R895-920 Medical Physics/Medical Radiology
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre of Biomedical Physics [wef 2021 changed to Research Centre for Applied Physics and Radiation Technologies and moved to SET ]
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 11 Mar 2021 07:22
Last Modified: 11 Mar 2021 07:22

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