Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy

Chew, Ming Tsuey * and Jones, B. and Hill, M. and Bradley, D.A. (2021) Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy. Radiation Physics and Chemistry, 178. p. 108994. ISSN 0969-806X

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Official URL: http://doi.org/10.1016/j.radphyschem.2020.108994


Radiations in medicine cover a wide range of applications, predominantly in diagnostic imaging and radiotherapy, encompassing photons (x- andγ-rays) and particle radiation, as well as with the use of liquid sources in nuclear medicine focusing on physiological functional imaging, tumour detection or targeted radiotherapy. The biological interactions of ionizing radiation leads naturally to questions of benefits and risk following dose exposures. The inherent properties of ionizing radiation in sterilising dividing cells can offer immense benefits withrespectto tumourcontrol,butradiationcanalsodeliverpotentialharminthe formofnormaltissue toxicity or carcinogenesis. The advances in radiation technology, offering accurate and reliable dose delivery, in concert with greater understanding of the underpinning radiobiological effects are creating an ever-growing ability to extract maximum benefit and minimise risk. The radiobiological effects fall broadly under the headings of mutagenesis, chromosomal aberrations, radiation induced genomic instability and cell death. The enormity of evidence derived from these underlie the mechanism of the six Rs of controlled radiotherapy: repair, repopulation, reoxygenation, redistribution, radiosensitivity and most recently, remote bystander cellular effects (including low dose hyper-radiosensitivity, adaptive response, hormesis, abscopal effect and immune response). Herein, we seek to discuss how such understanding leads to optimised radiotherapy.

Item Type: Article
Uncontrolled Keywords: Two-edged sword; Radiobiological effect; Chromosomal aberrations; 6 Rs of Radiobiology
Subjects: R Medicine > R Medicine (General) > R895-920 Medical Physics/Medical Radiology
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre of Biomedical Physics [wef 2021 changed to Research Centre for Applied Physics and Radiation Technologies and moved to SET ]
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 14 Dec 2020 03:40
Last Modified: 14 Dec 2020 03:46
URI: http://eprints.sunway.edu.my/id/eprint/1542

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