Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients.

Chen, Ew-Jun * and Tan, Teik Hin * and Chew, Ming Tsuey * (2021) Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. Radiation Physics and Chemistry, 178. p. 108998. ISSN 0969806X

Chew Ming Tsuey Superscan-superiority of xSPECT-CT over OSEM SPECT-CT in bone scans of prostate cancer patients (003).pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (3MB) | Preview
Official URL:


Prostate cancer is one of the most common cancers affecting men. Bone scan is part of the staging modality commonly used to evaluate bone metastasis. A bone scan with diffused increased skeletal tracer uptake relative to soft tissue, combined with faint renal activity is known as a superscan. However, a primary concern are false negatives associated with bone scans, where diffuse metastasis is indistinguishable on superscans. In this study, we performed xSPECT/CT Bone and standard OSEM SPECT/CT reconstruction algorithm in ten prostate cancer patients with high PSA levels, where they initially seem relatively unremarkable on planar images. All patients with extensive bone metastases showed either relatively unremarkable scans or did not demonstrate the true extent of metastatic burden as seen on planar images. Uptake was further confirmed by the correlative diffuse bone lesions on CT images. Our reports also indicated that xSPECT/CT reconstructed images were far superior in delineating focal areas of osteoblastic bone metastasis, when compared with whole body planar images or SPECT/CT images. The extent of metastatic evidence is delineated with excellent clarification by xSPECT/CT images. We propose that whole body xSPECT/CT image reconstruction, or at least SPECT/CT, should be performed in patients with high PSA levels, along with planar imaging, to improve diagnostic accuracy of bone scans in prostate cancer staging.

Item Type: Article
Uncontrolled Keywords: Prostate cancer; skeletal; scintigraphy; metastasis; xSPECT/CT SPECT/CT
Subjects: R Medicine > R Medicine (General) > R895-920 Medical Physics/Medical Radiology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre of Biomedical Physics [wef 2021 changed to Research Centre for Applied Physics and Radiation Technologies and moved to SET ]
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 14 Dec 2020 02:43
Last Modified: 14 Dec 2020 04:08

Actions (login required)

View Item View Item