Comorbidity network analyses of global rheumatoid arthritis and Type 2 diabetes reveal IL2 & IL6 as common role players

Liew, Tuck Onn * and Mishra, Rohit and Lahiri, Chandrajit * (2020) Comorbidity network analyses of global rheumatoid arthritis and Type 2 diabetes reveal IL2 & IL6 as common role players. In: Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science, vol 12108. Springer, Cham, pp. 227-236. ISBN 978-3-030-45385-5

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Comorbidities are associated with harder clinical management, worse health outcomes and an overall increase in healthcare expenditure. Here, we present a novel method of finding the common key genes and pathways via comorbidity network analyses. Essentially, we deployed data from the RAvariome database and Type 2 Diabetes Knowledge Portal for mutually exclusive interpopulation RA and T2D susceptibility genes, respectively. Protein interactomes (PIN) are built by mapping direct interactions between the above gene products and their interacting partners, along with a comorbid network combining both RA and T2D PIN. Network centrality analyses of all PIN projected 18 overlapping proteins with IL-6 and IL-2 being the common key role players found in the comorbid PIN, despite being exclusive to our curated RA susceptible gene list. Subsequent pathway analyses revealed the involvement of cellular senescence, MAPK and AGE-RAGE signalling in diabetic complications. We conclude that RA and T2D susceptible genes do not necessarily translate into indispensable proteins in their induced individual or comorbid diseased networks, but those of RA can outcompete T2D susceptible genes despite the much larger T2D component in the comorbid network. Our method is a unique approach to find key genes/proteins and implicated pathways in disease comorbidities.

Item Type: Book Section
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Others > Non Sunway Academics
Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Dept. Biological Sciences moved to SMLS wef 2021
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 30 Sep 2020 07:42
Last Modified: 30 Sep 2020 07:42

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