Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers

Lim, Hui Xuan * and Kim, Tae Sung and Poh, Chit Laa * (2020) Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers. International Journal of Molecular Sciences, 21 (10). p. 3599. ISSN 1422-0067

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Official URL: http://doi.org/10.3390/ijms21103599

Abstract

There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function of MDSCs is suppressing anti-tumor immune responses by impairing T cell functions, and these cells are the most important players in cancer dissemination and metastasis. Therefore, understanding the factors and the mechanism of MDSC differentiation, expansion, and recruitment into the tumor microenvironment can lead to its control. However, most of the studies only defined MDSCs with no further characterization of granulocytic and monocytic subsets. In this review, we discuss the mechanisms by which specific MDSC subsets contribute to cancers. A better understanding of MDSC subset development and the specific molecular mechanism is needed to identify treatment targets. The understanding of the specific molecular mechanisms responsible for MDSC accumulation would enable more precise therapeutic targeting of these cells.

Item Type: Article
Uncontrolled Keywords: MDSC subsets; G-MDSCs; M-MDSCs; cancers; immunosuppression
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 03 Jun 2020 03:06
Last Modified: 03 Jun 2020 03:06
URI: http://eprints.sunway.edu.my/id/eprint/1300

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