Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC)

Pang, Siew Wai * and Awi, Noel Jacques * and Armon, Subasri and Lim, Wendy Wan-Dee and Low, John Seng-Hooi and Peh, Kaik-Boo and Peh, Suat Cheng * and Teow, Sin Yeang * (2019) Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC). Diagnostics, 10 (1). p. 9. ISSN 2075-4418

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Official URL: http://doi.org/10.3390/diagnostics10010009

Abstract

Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles. While the treatment of CRC has seen significant improvement since the advent of target-specific therapies and personalized medicine, CRC is oftentimes detected at late or advanced stages, thereby reducing the efficacy of treatment. Hence, screening for early detection is still the key to combat CRC and to increase overall survival (OS). Considering that the field of medical diagnostics is moving towards molecular diagnostics, CRC can now be effectively screened and diagnosed with high accuracy and sensitivity. Depending on the tumor genotype and genetic profile of the individual, personalized treatments including tyrosine kinase inhibitor therapy and immunotherapy can be administered. Notably, there can be no one single treatment that is effective for all CRC patients due to the variation in tumor genetics, which highlights the importance of molecular diagnostics. This review provides insights on therapeutic modalities, molecular biomarkers, advancement of diagnostic technologies, and current challenges in managing CRC.

Item Type: Article
Additional Information: (This article belongs to the Special Issue Novel Approaches in the Diagnosis of Primary and Secondary Disease within Colorectal Cancer)
Uncontrolled Keywords: colorectal cancer; molecular; diagnostics; biomarker; technologies; personalized medicine; therapy; genetic; screening; challenges
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Others > Non Sunway Academics
Sunway University > School of Healthcare and Medical Sciences
Sunway University > School of Healthcare and Medical Sciences > Department of Nursing
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 31 Dec 2019 01:59
Last Modified: 31 Dec 2019 01:59
URI: http://eprints.sunway.edu.my/id/eprint/1198

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