Impact of genetic changes in the Enterovirus 71 genome on virulence

Poh, Chit Laa * and Mandary, M. B. and Ong, Seng Kai * (2019) Impact of genetic changes in the Enterovirus 71 genome on virulence. In: Virus. CRC Press.

[img] Text
Virus_Chapter_Poh Chit Laa.docx - Published Version
Available under License Creative Commons Attribution.

Download (13kB)

Abstract

Enterovirus 71 (EV-A71) is one of the main etiological agents of hand, foot and mouth disease (HFMD). EV-A71 mainly infects infants and young children below six years of age. Clinical manifestations of HFMD include fever, rashes with the presence of vesicles on the hand, feet and mouth. However, the onset of severe HFMD can lead to neurological complications such as acute flaccid paralysis, brainstem encephalitis and cardiac pulmonary failure that can be fatal. This chapter addresses how genetic events such as recombination and spontaneous mutations could change the genomic organization of EV-A71, leading to strains with higher virulence. An understanding of the recombination mechanism of the poliovirus and non-polio enteroviruses provides evidence for the emergence of novel EV-A71 strains responsible for fatal HFMD outbreaks. Currently, it is unknown if the virulence of EV-A71 is contributed by the events of recombination between EV-A71 and other enteroviruses or it is due to the presence of spontaneous mutations that affect its virulence.

Item Type: Book Section
Uncontrolled Keywords: EV-A71; Enterovirus 71, RNA, epidemiology; recombination; spontaneous mutations; virulence, viral fitness, pathogenecity, antigenicity
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Dept. Biological Sciences
Sunway University > School of Science and Technology > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 20 Dec 2019 03:55
Last Modified: 20 Dec 2019 03:55
URI: http://eprints.sunway.edu.my/id/eprint/1191

Actions (login required)

View Item View Item