Non-microbial natural products that inhibit drug-resistant Staphylococcus aureus

Chew, Jactty * and Peh, Suat Cheng * and Teow, Sin Yeang * (2018) Non-microbial natural products that inhibit drug-resistant Staphylococcus aureus. In: Staphylococcus Aureus. InTech Open, London,UK. ISBN 978-1-78984-593-8

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Official URL: http://doi.org/10.5772/intechopen.74588

Abstract

Drug resistance developed in human pathogenic bacteria is emerging and has become a global problem. Methicillin-resistant Staphylococcus aureus (MRSA) spreading in both hospital and community areas has posed a great impact to global public health. Current antibiotics used against these resistant strains are no longer efficacious and the search for new alternative is in urgent need. In the past decades, natural products have demonstrated multiple biological activities in biomedical areas including their antibacterial actions against various drug-resistant bacteria. More promisingly, some natural products could reverse the resistance of bacteria to the antibiotics, making the target bacteria susceptible to these drugs again. Numerous natural products have also exhibited potent synergism against the drug-resistant bacteria when used in combination with various types of antibiotics. Recently, several antibacterials derived from microbes have been developed and approved by Food and Drug Administration (FDA) for clinical use. In this chapter, we discuss the potential use of non-microbial natural products in controlling Staphylococcus aureus (S. aureus)‘s growth, and the underlying challenges in developing the natural products into clinical applications.

Item Type: Book Section
Uncontrolled Keywords: natural products; Staphylococcus aureus; methicillin-resistant; antibacterial; MRSA
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Sunway University > School of Science and Technology > Dept. Biological Sciences
Sunway University > School of Healthcare and Medical Sciences > Department of Medical Sciences
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 27 Nov 2019 07:40
Last Modified: 27 Nov 2019 07:40
URI: http://eprints.sunway.edu.my/id/eprint/1146

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