Development of universal influenza vaccines targeting conserved viral proteins

Jazayeri, S. D. * and Poh, Chit Laa * (2019) Development of universal influenza vaccines targeting conserved viral proteins. Vaccines, 7 (4). p. 169. ISSN 2076-393X

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Official URL: http://doi.org/10.3390/vaccines7040169

Abstract

Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza vaccines mostly induce antibody responses to the surface proteins of influenza viruses, which frequently change due to antigenic shift and or drift, thus allowing influenza viruses to avoid neutralizing antibodies. Hence, influenza vaccines need a yearly formulation to protect against new seasonal viruses. A broadly protective or universal influenza vaccine must induce effective humoral as well as cellular immunity against conserved influenza antigens, offer good protection against influenza pandemics, be safe, and have a fast production platform. Nanotechnology has great potential to improve vaccine delivery, immunogenicity, and host immune responses. As new strains of human epidemic influenza virus strains could originate from poultry and swine viruses, development of a new universal influenza vaccine will require the immune responses to be directed against viruses from different hosts. This review discusses how the new vaccine platforms and nanoparticles can be beneficial in the development of a broadly protective, universal influenza vaccine.

Item Type: Article
Uncontrolled Keywords: seasonal influenza vaccine; universal influenza vaccine; humoral and cell-mediated immunity; conserved viral proteins
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Sunway University > School of Science and Technology > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 25 Nov 2019 01:39
Last Modified: 25 Nov 2019 01:39
URI: http://eprints.sunway.edu.my/id/eprint/1124

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