Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.

Loo, Kong Yong and Leong, Kok Hoong and Yasodha Sivasothy, * and Halijah Ibrahim, and Khalijah Awang, (2019) Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. Chemistry & Biodiversity, 16 (6). e1900032. ISSN 1612-1872

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Official URL: http://doi.org/10.1002/cbdv.201900032

Abstract

The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Others > Non Sunway Academics
Depositing User: Dr Janaki Sinnasamy
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Date Deposited: 15 Nov 2019 01:42
Last Modified: 15 Nov 2019 01:45
URI: http://eprints.sunway.edu.my/id/eprint/1121

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