Recent advances in delivery of veterinary DNA vaccines against avian pathogens

Jazayeri, S. D. * and Poh, Chit Laa * (2019) Recent advances in delivery of veterinary DNA vaccines against avian pathogens. Veterinary Research, 50 (78). ISSN 1297-9716

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Official URL: http://doi.org/10.1186/s13567-019-0698-z

Abstract

Veterinary vaccines need to have desired characteristics, such as being effective, inexpensive, easy to administer, suitable for mass vaccination and stable under field conditions. DNA vaccines have been proposed as potential solutions for poultry diseases since they are subunit vaccines with no risk of infection or reversion to virulence. DNA vaccines can be utilized for simultaneous immunizations against multiple pathogens and are relatively easy to design and inexpensive to manufacture and store. Administration of DNA vaccines has been shown to stimulate immune responses and provide protection from challenges in different animal models. Although DNA vaccines offer advantages, setbacks including the inability to induce strong immunity, and the fact that they are not currently applicable for mass vaccination impede the use of DNA vaccines in the poultry industry. The use of either biological or physical carriers has been proposed as a solution to overcome the current delivery limitations of DNA vaccines for veterinary applications. This review presents an overview of the recent development of carriers for delivery of veterinary DNA vaccines against avian pathogens.

Item Type: Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Sunway University > School of Science and Technology > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
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Date Deposited: 14 Oct 2019 03:33
Last Modified: 22 Oct 2019 09:36
URI: http://eprints.sunway.edu.my/id/eprint/1114

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