Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer

Nur Izyani K, and Noraini Abd Aziz, * and Poh, Chit Laa * and Chowdhury, Ezharul Hoque (2019) Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer. Cancers, 11 (5). p. 632. ISSN 2072-6694

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Official URL: http://doi.org/10.3390/cancers11050632


Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways.

Item Type: Article
Uncontrolled Keywords: breast cancer; siRNA; cell signaling; active targeting; passive targeting; EPR effect; oncogenes; nanoparticles; nanomedicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Centre for Virus and Vaccine Research
Depositing User: Dr Janaki Sinnasamy
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Date Deposited: 06 Sep 2019 07:21
Last Modified: 06 Sep 2019 09:25
URI: http://eprints.sunway.edu.my/id/eprint/1093

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