A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism

Phei, Felicia Lin Lim and Tan, Khai Ching and Luna, Giuseppe and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2019) A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism. Tetrahedron, 75 (15). pp. 2314-2321. ISSN 0040-4020

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It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and under conventional heating mimicking the microwave heating pattern. X-ray crystallography identified two different types of tautomers in crystals of related 5-aminopyrazoles with p-toluidyl and p-anisidyl moieties at the position 3, respectively.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Others > Non Sunway Academics
Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Research Centre for Crystalline Materials moved to SMLS wef 2021
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 12 Apr 2019 05:51
Last Modified: 07 Oct 2020 08:42
URI: http://eprints.sunway.edu.my/id/eprint/1021

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